Presant C A, Bartolucci A A
Med Pediatr Oncol. 1984;12(1):25-7. doi: 10.1002/mpo.2950120107.
Twenty-nine evaluable patients with anthracycline-resistant metastatic bone or soft tissue sarcomas were treated with chlorozotocin, 150 mg/m2 every 6 weeks. Four patients (14%) achieved partial responses. The most severe toxicity was usually thrombocytopenia (which occurred in 31% of patients). Chlorozotocin has only minimal activity in drug-resistant metastatic sarcomas.
29例可评估的对蒽环类药物耐药的转移性骨肉瘤或软组织肉瘤患者接受了氯脲霉素治疗，剂量为每6周150mg/m²。4例患者（14%）获得部分缓解。最严重的毒性通常是血小板减少（31%的患者出现）。氯脲霉素在耐药转移性肉瘤中只有极小的活性。
