Mark I
Scand J Soc Med. 1983;11(3):75-80.
A study of 69 female drug addicts is presented who have been given depomedroxyprogesterone acetate (DMPA) as a contraceptive for 1 680 woman-months. No pregnancies were reported during the treatment period with DMPA. After stopping treatment, 60 pregnancies with 43 births were recorded, 12 with low birth weight. In 3 cases pregnancy ended with spontaneous abortion, and in 14 cases legal abortion were performed. During the study, regular liver function tests revealed no hepatotoxic effects from DMPA in this group of patients where one would expect a high frequency of a serum hepatitis. Neither coagulation nor blood pressure were affected. The most frequent side effect was amenorrhoea, which seems to be accepted well in this group. Metrorrhagia is often a reason for withdrawing the drug. A very high frequency of venereal or other gynaecological infection is presumably the explanation for the very high number of atypical inflammation cells found at vaginal cytological examination. In the series, two cases of carcinoma in situ have been demonstrated by cervical biopsy. Both cases are possibly related to these women's early sexual activity, very promiscuous life and to the poor environment of the drug addict.
本文介绍了一项对69名女性吸毒者的研究，她们使用醋酸甲羟孕酮长效注射剂（DMPA）作为避孕药具，累计使用时长为1680妇女月。在使用DMPA治疗期间未报告妊娠情况。停止治疗后，记录到60次妊娠，其中43例分娩，12例为低体重儿。3例妊娠以自然流产告终，14例行人工流产。研究期间，定期肝功能检查显示，在这组预期血清性肝炎高发的患者中，DMPA未产生肝毒性作用。凝血功能和血压均未受影响。最常见的副作用是闭经，该组患者对此似乎接受良好。子宫出血常是停药的原因。在阴道细胞学检查中发现大量非典型炎症细胞，推测是由于性传播疾病或其他妇科感染的高发病率所致。在该系列研究中，经宫颈活检证实有2例原位癌。这两例可能都与这些女性过早的性活动、极其混乱的生活方式以及吸毒者的恶劣环境有关。
