Wells P W, Robinson J T, Gilmour N J, Donachie W, Sharp J M
Vet Rec. 1984 Mar 17;114(11):266-9. doi: 10.1136/vr.114.11.266.
The efficacy of a multicomponent clostridial vaccine containing Pasteurella haemolytica antigens was tested in specific pathogen free or conventionally reared lambs exposed to experimental infection with P haemolytica serotypes A1, A2 or A6. In four experiments assessment was based upon the findings of clinical, pathological and bacteriological examinations. Three experiments carried out in conventionally reared lambs demonstrated protection against challenge infection with P haemolytica serotypes A1, A2 and A6 in vaccinated lambs. However, the inconsistency of the disease induced in these experiments emphasised the need to perform definitive studies in specific pathogen free conditions. The final experiment was carried out with specific pathogen free lambs and confirmed the efficacy of the multicomponent clostridial vaccine containing P haemolytica antigen in protecting against the effects of infection with P haemolytica serotype A6. In addition, this experiment indicated that the inclusion of several components in a vaccine did not affect the efficacy of an individual antigenic component.
一种含有溶血巴氏杆菌抗原的多组分梭菌疫苗，在接触了溶血巴氏杆菌A1、A2或A6血清型实验性感染的无特定病原体或常规饲养的羔羊身上进行了功效测试。在四项实验中，评估基于临床、病理和细菌学检查结果。在常规饲养的羔羊身上进行的三项实验表明，接种疫苗的羔羊对溶血巴氏杆菌A1、A2和A6血清型的攻击感染具有保护作用。然而，这些实验中诱发疾病的不一致性强调了在无特定病原体条件下进行确定性研究的必要性。最后一项实验是用无特定病原体的羔羊进行的，证实了含有溶血巴氏杆菌抗原的多组分梭菌疫苗在预防溶血巴氏杆菌A6血清型感染影响方面的功效。此外，该实验表明，疫苗中包含几种成分不会影响单个抗原成分的功效。
