[己酸17-α-羟孕酮和醋酸甲羟孕酮对大鼠胶原蛋白生物合成及四氯化碳诱导的肝损伤肝硬化进程的不同作用]
[Diverse action of 17-alpha-hydroxyprogesterone caproate and medroxyprogesterone acetate on the biosynthesis of collagen and cirrhogenous course of CC14-induced hepatic lesions in rats].
作者信息
Gambella G R, Burlando F, Vascotto E, Novelli A
出版信息
Arch Sci Med (Torino). 1983 Oct-Dec;140(4):413-6.
PMID:6231903
Abstract
The administration of medroxyprogesterone acetate to rats did not induce rapidly progressing cirrhosis in livers damage by carbon tetrachloride, as had occurred after the administration of 17-alpha-hydroxyprogesterone caprate. Even after two months' treatment with medroxyprogesterone acetate and CC14, the cirrhosis did not reach the levels obtained in a single month with the association of 17-alpha-hydroxyprogesterone and CC14.
摘要
给大鼠注射醋酸甲羟孕酮，并不会像注射癸酸17-α-羟基孕酮后那样，在四氯化碳造成肝脏损伤的情况下诱发快速进展性肝硬化。即使在醋酸甲羟孕酮和四氯化碳联合治疗两个月后，肝硬化程度仍未达到17-α-羟基孕酮与四氯化碳联合使用一个月时所达到的水平。
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