Malick A P, Garner R E, Black S P, Elgert K D
Cell Immunol. 1984 May;85(2):549-55. doi: 10.1016/0008-8749(84)90267-3.
The mixed-lymphocyte reaction reactivity of normal and tumor-bearing host (TBH) T-cell subsets was examined in response to normal and TBH macrophage (M phi) supernatants. Both inhibiting and enhancing activities were identified in normal and TBH M phi supernatants. The present data suggest that TBH M phi supernatants contained more inhibitory activity than normal host M phi supernatants and that enhancing activity of M phi supernatants was restricted to the Lyt 2,3+ population of cells. TBH Lyt 2,3+ cells were more responsive to the enhancing molecule(s) than their normal counterparts. These data were consistent with studies which implicate M phi as being partially responsible for the immune dysfunction seen in TBH, and extends previous findings on the ability of M phi to regulate the immune response in an attempt to achieve homeostasis.
检测了正常宿主和荷瘤宿主（TBH）T细胞亚群对正常巨噬细胞（M phi）上清液和TBH巨噬细胞上清液的混合淋巴细胞反应活性。在正常和TBH巨噬细胞上清液中均鉴定出抑制和增强活性。目前的数据表明，TBH巨噬细胞上清液比正常宿主巨噬细胞上清液含有更多的抑制活性，并且巨噬细胞上清液的增强活性仅限于Lyt 2,3 +细胞群体。TBH Lyt 2,3 +细胞比正常对应细胞对增强分子更敏感。这些数据与将巨噬细胞视为TBH中免疫功能障碍部分原因的研究一致，并扩展了先前关于巨噬细胞调节免疫反应以实现体内平衡能力的研究结果。
