Ishiwata K, Ido T, Kawashima K, Murakami M, Takahashi T
Eur J Nucl Med. 1984;9(4):185-9. doi: 10.1007/BF00251469.
18F-labeled 5-fluorouracil(FUra), 5-fluoro-2'-deoxyuridine(FdUrd), and 5-fluorouridine ( FUrd ) were synthesized with high radiochemical purities. The 18F-labeled pyrimidines were injected into rats. The metabolites in serum, bile, and urine were analyzed up to 2 h after administration by radio-high performance liquid chromatography (HPLC). The blood clearance of three pyrimidines was very rapid. In the serum the nucleosides and base disappeared very rapidly with a biological half-life of about 2 min and most of them had disappeared by 60 min. The metabolites in the urine were similar to those in the serum. In the bile pyrimidine nucleosides and base were not detected. 18F- was found in the metabolites. Our results explain the high uptakes in the kidney and liver in biodistribution studies of the 18F-labeled pyrimidines.
合成了具有高放射化学纯度的18F标记的5-氟尿嘧啶（FUra）、5-氟-2'-脱氧尿苷（FdUrd）和5-氟尿苷（FUrd）。将18F标记的嘧啶注入大鼠体内。给药后2小时内，通过放射性高效液相色谱（HPLC）分析血清、胆汁和尿液中的代谢物。三种嘧啶的血液清除非常迅速。血清中的核苷和碱基消失得非常快，生物半衰期约为2分钟，大部分在60分钟内就已消失。尿液中的代谢物与血清中的相似。在胆汁中未检测到嘧啶核苷和碱基。在代谢物中发现了18F。我们的结果解释了在18F标记的嘧啶生物分布研究中肾脏和肝脏的高摄取情况。
