血管活性肠肽对胆囊平滑肌的体外作用。 （注：原文中“Efffect”拼写错误，应为“Effect”）
Efffect of vasoactive intestinal polypeptide on gallbladder smooth muscle in vitro.
作者信息
Ryan J P, Ryave S
出版信息
Am J Physiol. 1978 Jan;234(1):E44-6. doi: 10.1152/ajpendo.1978.234.1.E44.
The effect of vasoactive intestinal polypeptide (VIP) on basal and octapeptide of cholecystokinin (OP-CCK) induced tension was examined with guinea pig gallbladder smooth muscle strips in vitro. VIP alone produced dose-related decreases in resting tension and antagonized spontaneous contractile activity where present. In combination with OP-CCK, VIP decreased the expected contractile respone. The degree of antagonism depended upon the concentrations of OP-CCK and VIP. VIP had no effect on acetylcholine-induced contractions. From these observations, we propose that VIP can affect gallbladder motor activity by decreaseing smooth muscle tone and by antagonizing cholecystokinin. These findings lend further support to our proposal that gallbladder motor function may depend upon the action and interaction of the gastrointestinal hormones.
采用豚鼠胆囊平滑肌条，在体外研究了血管活性肠肽（VIP）对基础张力及八肽胆囊收缩素（OP-CCK）诱导张力的影响。单独使用VIP可使静息张力呈剂量依赖性降低，并拮抗已有的自发收缩活动。与OP-CCK联合使用时，VIP可降低预期的收缩反应。拮抗程度取决于OP-CCK和VIP的浓度。VIP对乙酰胆碱诱导的收缩无影响。基于这些观察结果，我们提出VIP可通过降低平滑肌张力和拮抗胆囊收缩素影响胆囊运动活性。这些发现进一步支持了我们的观点，即胆囊运动功能可能取决于胃肠激素的作用及相互作用。
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