[Stereological analysis of the parenchymal and stromal structures of a hypertrophied myocardium in acute arterial hypertension].

Arterial hypertension in 35 male Wistar rats was produced by disturbance of the left renal artery circulation. Myocardial tissue reorganization was studied by using the methods of light microscopy and stereological analysis. By the 35th day of the experiment marked alterations of the intramural vessels were found which were manifested in the thickening of the vessel walls due to hyperplasia and hypertrophy of the smooth muscles cells, and in the developing of sclerotic processes in all layers of the arterial walls. At the tissue level a decrease of the volume and surface densities of capillaries and connective tissue cells were determined, that resulted in a decline of the ratio between the volume and surface densities of the structures to the volume density of cardiomyocytes. Informational analysis revealed an increase of entropy and relative entropy of the myocardium tissue during its hypertrophy.