Winkler K, Skovgård L T
Clin Physiol. 1984 Apr;4(2):135-46. doi: 10.1111/j.1475-097x.1984.tb00229.x.
A method for separate determinations of liver and spleen reticuloendothelial function, using a small-size 99Tcm -antimony sulphide colloid and gamma camera technique, is described. Several methods for achieving blood-background correction are examined, and it is shown that, by a three-compartment model, the use of a specific blood pool tracer can be dispensed with. Hepatic and splenic uptake of the colloid can be described by first order kinetics, and can be calculated to an error less than 5%. In a reference material (n = 13), hepatic and splenic clearance was 262 ml/min (100-412) and 22 ml/min (0-62), respectively. In cirrhosis (n = 7), hepatic clearance was decreased and splenic clearance increased. The results indicate that this method, which is well suited for clinical studies and which is based on a reasonable physiologic model, in cirrhosis of the liver demonstrates a decreased hepatic reticuloendothelial function with (compensatory?) increase in that of the spleen.
本文描述了一种使用小剂量99锝-硫化锑胶体和γ相机技术分别测定肝脏和脾脏网状内皮系统功能的方法。研究了几种实现血液本底校正的方法，结果表明，通过三室模型，可以不用使用特定的血池示踪剂。胶体在肝脏和脾脏的摄取可用一级动力学描述，计算误差小于5%。在一个参考材料组（n = 13）中，肝脏和脾脏的清除率分别为262 ml/min（100 - 412）和22 ml/min（0 - 62）。在肝硬化组（n = 7）中，肝脏清除率降低，脾脏清除率增加。结果表明，这种基于合理生理模型且非常适合临床研究的方法，在肝硬化时显示肝脏网状内皮系统功能降低，而脾脏功能（代偿性？）增加。
