Geis G S, Barratt G, Wurster R D
Am J Physiol. 1978 Feb;234(2):H152-6. doi: 10.1152/ajpheart.1978.234.2.H152.
Resting cardiovascular parameters and the responses to bilateral carotid occlusions (BCO) were monitored in pentobarbital-anesthetized and conscious dogs before and after placing lesions in the dorsolateral funiculi at C7-C8 and after spinal transections at C7. Pre- and postlesion blood pressure (BP) and heart rate (HR) responses to exercise were also monitored. The lesions significantly attenuated the responses to BCO and decreased resting BP in anesthetized dogs. Yet neither resting HR in anesthetized or conscious dogs nor the resting BP in conscious dogs was affected by the lesions. Subsequent spinal transections significantly decreased resting HR and BP and the responses to BCO but did not affect the BP response to BCO in anesthetized dogs as compared with corresponding postlesion parameters. BP responses to exercise were significantly attenuated by the lesions, but HR responses were not affected. Since stimulation and BP studies indicated that the descending pressor pathway had been ablated, the data suggest that the pathway mediates BP and HR responses to BCO in pentobarbital-anesthetized and conscious dogs. It does not maintain resting HR in anesthetized or conscious animals, and the resting BP in conscious dogs. This pathway is important for BP responses to exercise but is not necessary for HR responses. Finally, other spinal pathways are involved in cardiovascular control.
在戊巴比妥麻醉和清醒的犬中，于C7 - C8节段的背外侧索放置损伤前、后以及在C7水平进行脊髓横断后，监测静息心血管参数和对双侧颈动脉闭塞（BCO）的反应。还监测了损伤前、后运动时的血压（BP）和心率（HR）反应。这些损伤显著减弱了麻醉犬对BCO的反应，并降低了其静息血压。然而，麻醉或清醒犬的静息心率以及清醒犬的静息血压均未受这些损伤影响。随后的脊髓横断显著降低了静息心率和血压以及对BCO的反应，但与相应的损伤后参数相比，并未影响麻醉犬对BCO的血压反应。损伤显著减弱了运动时的血压反应，但心率反应未受影响。由于刺激和血压研究表明下行降压通路已被切断，数据提示该通路介导了戊巴比妥麻醉和清醒犬对BCO的血压和心率反应。它并不维持麻醉或清醒动物的静息心率以及清醒犬的静息血压。该通路对运动时的血压反应很重要，但对心率反应并非必需。最后，其他脊髓通路也参与心血管控制。
