Köpke K, Dittrich F, Berlin P
Pharmazie. 1984 Mar;39(3):173-6.
Knowing the modell developed by Repke and co-workers for the cardenolide-receptor-interaction the aim of this study was to find quantitative relations between molecular physical properties of cardenolides and their molecular-biologically defined effect, which are fundamentally useful to estimate the effect of still nonsynthesized cardenolide derivatives. The statistically significant relations (alpha = 0.05) between molecular physical parameters, which are derived from the dipole moment vector, and the molecular-biologically defined effect was found by means of regression analysis.
基于Repke及其同事开发的强心甾受体相互作用模型，本研究旨在寻找强心甾的分子物理性质与其分子生物学定义效应之间的定量关系，这对于评估尚未合成的强心甾衍生物的效应具有根本上的实用性。通过回归分析，发现了源自偶极矩矢量的分子物理参数与分子生物学定义效应之间具有统计学意义的关系（α = 0.05）。
