Wikström A, Green B, Johansson E D
Acta Obstet Gynecol Scand. 1984;63(2):163-8. doi: 10.3109/00016348409154654.
Peripheral plasma levels of medroxyprogesterone acetate (MPA) were determined by radioimmunoassay in 5 women after oral administration of 5 and 10 mg medroxyprogesterone acetate daily. Peak levels of MPA in plasma were recorded within 1 - 3 hours of taking the tablet, which indicates a rapid absorption from the gastro-intestinal tract. The levels of medroxyprogesterone acetate 12 hours after taking of the 5 mg tablet remained constant throughout the 8 weeks of study. Peripheral plasma levels of estradiol and progesterone were determined throughout treatment. The estradiol levels indicated development of follicles in 7 out of 10 treatment months in the 5 mg group, and in 3 of the subjects treated with 10 mg MPA. The progesterone levels in those women treated with 5 mg MPA showed normal luteal concentration values in 2 out of 10 treatment months. No woman treated with 10 mg MPA had an increase in progesterone during the 21-day period of treatment. The results obtained in this study suggest that 10 mg MPA daily will inhibit ovulation but 5 mg is not sufficient to inhibit ovulation in all women.
通过放射免疫分析法测定了5名女性每日口服5毫克和10毫克醋酸甲羟孕酮（MPA）后的外周血浆中醋酸甲羟孕酮水平。服药后1 - 3小时内记录到血浆中MPA的峰值水平，这表明其从胃肠道吸收迅速。服用5毫克片剂12小时后，醋酸甲羟孕酮水平在整个8周的研究期间保持恒定。在整个治疗过程中测定了外周血浆中雌二醇和孕酮的水平。在5毫克组10个治疗月中的7个月以及接受10毫克MPA治疗的3名受试者中，雌二醇水平表明有卵泡发育。接受5毫克MPA治疗的女性中，孕酮水平在10个治疗月中的2个月显示出正常的黄体期浓度值。在接受10毫克MPA治疗的女性中，在21天的治疗期间没有孕酮增加的情况。本研究获得的结果表明，每日10毫克MPA将抑制排卵，但5毫克不足以抑制所有女性的排卵。
