Michels M L, Cobo L M, Caldwell D S, Rice J R, Haynes B F
Arthritis Rheum. 1984 Jun;27(6):606-14. doi: 10.1002/art.1780270602.
Tissue immune effector cells and epithelial surface antigens present in eye tissue of rheumatoid arthritis (RA) patients with sterile corneal ulceration were studied using a large panel of monoclonal antibodies. During periods of active corneal ulceration, conjunctivae and corneas of all RA patients studied contained numerous immune-associated (Ia) antigen-positive tissue macrophages. In 4 of 6 patients, conjunctival or corneal T cell infiltrations were present. In 2 patients, a T cell vasculitis was seen in conjunctival tissue. Conjunctival epithelial cells of all 6 RA patients expressed Ia antigens during active corneal ulceration. These data provide evidence for immune-mediated mechanisms in the pathophysiology of corneal ulceration in RA. Moreover, the expression of Ia antigens by conjunctival epithelial cells may be a useful indicator of disease activity in RA patients with sterile corneal ulceration.
利用大量单克隆抗体研究了患有无菌性角膜溃疡的类风湿性关节炎（RA）患者眼部组织中的组织免疫效应细胞和上皮表面抗原。在角膜溃疡活动期，所有研究的RA患者的结膜和角膜都含有大量免疫相关（Ia）抗原阳性的组织巨噬细胞。6例患者中有4例出现结膜或角膜T细胞浸润。2例患者的结膜组织出现T细胞血管炎。在角膜溃疡活动期，所有6例RA患者的结膜上皮细胞均表达Ia抗原。这些数据为RA患者角膜溃疡病理生理学中的免疫介导机制提供了证据。此外，结膜上皮细胞Ia抗原的表达可能是患有无菌性角膜溃疡的RA患者疾病活动的有用指标。
