Thase M E, Tigner R, Smeltzer D J, Liss L
Biol Psychiatry. 1984 Apr;19(4):571-85.
Down's syndrome (DS) has been suggested as a high-risk condition for Dementia Alzheimer's type (DAT). In the present study, neuropsychological variables were assessed in 165 DS subjects and 163 matched mentally retarded controls. Overall, DS subjects had lower scores for orientation, digit span, visual memory, object-naming, and general knowledge, as well as more "released" reflexes. Impairments were most evident in DS subjects greater than 50 years old. These findings provide further support for an association between aging and DAT in Down's syndrome. Methodological issues and areas for future research are discussed.
唐氏综合征（DS）被认为是患阿尔茨海默病型痴呆（DAT）的高危病症。在本研究中，对165名唐氏综合征患者和163名匹配的智力迟钝对照者进行了神经心理学变量评估。总体而言，唐氏综合征患者在定向、数字广度、视觉记忆、物体命名和常识方面得分较低，并且有更多“释放”反射。在50岁以上的唐氏综合征患者中，损伤最为明显。这些发现为唐氏综合征中衰老与DAT之间的关联提供了进一步支持。文中讨论了方法学问题和未来研究的领域。
