J Clin Oncol. 1984 Jul;2(7):770-3. doi: 10.1200/JCO.1984.2.7.770.
In an attempt to confirm the previously reported response rates with methyl-CCNU, vincristine, 5-fluorouracil, and streptozotocin (MOF-strep) (34%) in advanced colorectal cancer, the Gastrointestinal Tumor Study Group used the identical treatment schedule in 40 good performance status patients who had received no prior chemotherapy. Four patients (10%) achieved an objective partial tumor response and the median survival for all patients was 7.3 months. The toxicity was evidenced by moderate nausea and vomiting and myelosuppression with one treatment-related death. Based on this trial further evaluation of MOF-strep for advanced colorectal cancer cannot be recommended.
为了证实先前报道的甲基环己亚硝脲、长春新碱、5-氟尿嘧啶和链脲佐菌素（MOF-链脲佐菌素）方案对晚期结直肠癌的缓解率（34%），胃肠道肿瘤研究组对40例既往未接受过化疗且身体状况良好的患者采用了相同的治疗方案。4例患者（10%）实现了客观的部分肿瘤缓解，所有患者的中位生存期为7.3个月。毒性表现为中度恶心、呕吐和骨髓抑制，有1例与治疗相关的死亡。基于该试验，不建议对MOF-链脲佐菌素方案用于晚期结直肠癌进行进一步评估。
