Filicheva V A, Lapchinskaia O A, Saburova T P, Siniagina O P, Ponomarenko V I
Antibiotiki. 1978 Jan;23(1):18-22.
The method of selecting active strains among a definite group of analogue-resistant mutants was used on the basis of studying the dependence of the carminomycin-producing organism growth and the antibiotic synthesis level on some metabolites. As a result, gamma-ray induced mutants 4 times more active than the parent strains were obtained.
基于研究卡那霉素产生菌的生长及抗生素合成水平对某些代谢物的依赖性,采用了从一组特定的抗类似物突变体中筛选活性菌株的方法。结果,获得了比亲本菌株活性高4倍的γ射线诱导突变体。