Bennett S R, Greer J P, Stein R S, Glick A D, Cousar J B, Collins R D
Am J Clin Pathol. 1984 Jul;82(1):104-9. doi: 10.1093/ajcp/82.1.104.
A case of mycosis fungoides in which pathologic rupture of the spleen led to intraperitoneal hemorrhage and death is described. To our knowledge, splenic rupture has not been reported previously as a cause of death in mycosis fungoides. Immunologic studies demonstrated that the neoplastic cell was a suppressor/cytotoxic T-cell. In most cases of mycosis fungoides or the Sézary syndrome, the neoplastic cell has been a helper/inducer T-cell. This case was very aggressive clinically with prominent visceral involvement and suggests that mycosis fungoides may be clinically diverse as well as immunologically heterogeneous.
本文描述了一例蕈样肉芽肿病例，该病例中脾脏的病理性破裂导致腹腔内出血并死亡。据我们所知，脾脏破裂此前尚未被报道为蕈样肉芽肿的死亡原因。免疫学研究表明，肿瘤细胞是一种抑制性/细胞毒性T细胞。在大多数蕈样肉芽肿或塞扎里综合征病例中，肿瘤细胞一直是辅助/诱导性T细胞。该病例临床侵袭性很强，有明显的内脏受累，提示蕈样肉芽肿在临床上可能具有多样性，在免疫学上也具有异质性。
