来自大鼠小肠黏膜的磷酸果糖激酶蛋白抑制剂。一种独立于葡萄糖的糖酵解调节机制。
A protein inhibitor of phosphofructokinase from the mucosa of rat small intestine. A mechanism for the regulation of glycolysis that is independent of glucose.
作者信息
Kellett G L, Robertson J P
出版信息
Biochem J. 1984 Jun 1;220(2):601-4. doi: 10.1042/bj2200601.
Abstract
A protein inhibitor of phosphofructokinase was detected by the chromatography on Sephadex G-100 of crude mucosal extracts prepared from the small intestine of starved rats. Addition of the protein inhibitor to extracts from fed rats increased the K0.5 of phosphofructokinase for fructose 6-phosphate to that for starved rats. The protein inhibitor provides a mechanism for the hormonal regulation of glycolysis independently of glucose supply.
摘要
通过对饥饿大鼠小肠制备的粗黏膜提取物进行葡聚糖凝胶G - 100柱色谱分析，检测到一种磷酸果糖激酶的蛋白抑制剂。将该蛋白抑制剂添加到喂食大鼠的提取物中，可使磷酸果糖激酶对6 - 磷酸果糖的半最大反应浓度（K0.5）增加到与饥饿大鼠相同的水平。这种蛋白抑制剂提供了一种独立于葡萄糖供应的糖酵解激素调节机制。
相似文献
1
A protein inhibitor of phosphofructokinase from the mucosa of rat small intestine. A mechanism for the regulation of glycolysis that is independent of glucose.来自大鼠小肠黏膜的磷酸果糖激酶蛋白抑制剂。一种独立于葡萄糖的糖酵解调节机制。
Biochem J. 1984 Jun 1;220(2):601-4. doi: 10.1042/bj2200601.
2
The effect of glucose on the activity of phosphofructokinase in the mucosa of rat small intestine.葡萄糖对大鼠小肠黏膜中磷酸果糖激酶活性的影响。
Biochem J. 1984 Mar 1;218(2):459-64. doi: 10.1042/bj2180459.
3
The effect of starvation on the control of phosphofructokinase activity in the epithelial cells of the rat small intestine.饥饿对大鼠小肠上皮细胞中磷酸果糖激酶活性调控的影响。
Biochem J. 1983 Jan 15;210(1):129-35. doi: 10.1042/bj2100129.
4
Properties of phosphofructokinase from the mucosa of rat jejunum and their relation to the lack of Pasteur effect.大鼠空肠黏膜磷酸果糖激酶的特性及其与巴斯德效应缺失的关系。
Biochem J. 1971 Nov;125(2):507-14. doi: 10.1042/bj1250507.
5
Regulation of mucosal phosphofructokinase in the small intestine of the streptozotocin-diabetic rat.链脲佐菌素诱导糖尿病大鼠小肠黏膜磷酸果糖激酶的调节
Diabetologia. 1983 Oct;25(4):355-9. doi: 10.1007/BF00253201.
6
Phosphofructokinase from the epithelial cells of rat small intestine. Comparison of regulatory properties with those of skeletal muscle, liver and brain phosphofructokinase.来自大鼠小肠上皮细胞的磷酸果糖激酶。与骨骼肌、肝脏和脑磷酸果糖激酶调节特性的比较。
Comp Biochem Physiol B. 1986;85(2):337-41. doi: 10.1016/0305-0491(86)90009-x.
7
The isolation and characterization of phosphofructokinase from the epithelial cells of rat small intestine.大鼠小肠上皮细胞中磷酸果糖激酶的分离与鉴定。
Biochem J. 1983 May 1;211(2):373-9. doi: 10.1042/bj2110373.
8
Glucose metabolism in the mucosa of the small intestine. Glycolysis in subcellular preparations from the cat and rat.小肠黏膜中的葡萄糖代谢。猫和大鼠亚细胞制剂中的糖酵解。
Biochem J. 1966 Aug;100(2):458-66. doi: 10.1042/bj1000458.
9
Effects of starvation and streptozotocin-induced diabetes on the activity of phosphofructokinase in the epithelial cells of rat colon.饥饿和链脲佐菌素诱导的糖尿病对大鼠结肠上皮细胞中磷酸果糖激酶活性的影响。
Biochimie. 1988 Jun;70(6):721-5. doi: 10.1016/0300-9084(88)90100-9.
10
The effect of thermal injury on the regulation of phosphofructokinase in the mucosa of rat small intestine.热损伤对大鼠小肠黏膜中磷酸果糖激酶调节的影响。
Biochimie. 1987 Jan;69(1):71-3. doi: 10.1016/0300-9084(87)90273-2.
引用本文的文献
1
Beta-adrenergic agents increase the phosphorylation of phosphofructokinase in isolated rat epididymal white adipose tissue.β-肾上腺素能药物可增加离体大鼠附睾白色脂肪组织中磷酸果糖激酶的磷酸化水平。
Biochem J. 1985 Dec 15;232(3):905-10. doi: 10.1042/bj2320905.
本文引用的文献
1
2
Fructose 2,6-bisphosphate. Hormonal regulation and mechanism of its formation in liver.果糖-2,6-二磷酸。其在肝脏中的激素调节及形成机制
J Biol Chem. 1981 Sep 10;256(17):8900-3.
3
4
Fructose 2,6-bisphosphate, the probably structure of the glucose- and glucagon-sensitive stimulator of phosphofructokinase.果糖2,6-二磷酸，可能是磷酸果糖激酶的葡萄糖和胰高血糖素敏感刺激物的结构。
Biochem J. 1980 Dec 15;192(3):897-901. doi: 10.1042/bj1920897.
5
Control of the fructose-6-phosphate/fructose 1,6-bisphosphate cycle in isolated hepatocytes by glucose and glucagon. Role of a low-molecular-weight stimulator of phosphofructokinase.葡萄糖和胰高血糖素对分离肝细胞中磷酸果糖-6-磷酸/果糖1,6-二磷酸循环的调控。磷酸果糖激酶低分子量刺激物的作用。
Biochem J. 1980 Dec 15;192(3):887-95. doi: 10.1042/bj1920887.
6
Changes in the concentration of activation factor for phosphofructokinase in hepatocytes in response to glucose and glucagon.肝细胞中磷酸果糖激酶激活因子浓度对葡萄糖和胰高血糖素的反应变化。
Biochem Biophys Res Commun. 1980 Dec 31;97(4):1535-40. doi: 10.1016/s0006-291x(80)80040-4.
7
Fructose 2,6-bisphosphate. A new activator of phosphofructokinase.果糖-2,6-二磷酸。磷酸果糖激酶的一种新激活剂。
J Biol Chem. 1981 Apr 10;256(7):3171-4.
8
Fructose 2,6-bisphosphate 2 years after its discovery.果糖2,6 -二磷酸在其发现两年后。
Biochem J. 1982 Jul 15;206(1):1-12. doi: 10.1042/bj2060001.
9
The effect of glucose on the activity of phosphofructokinase in the mucosa of rat small intestine.葡萄糖对大鼠小肠黏膜中磷酸果糖激酶活性的影响。
Biochem J. 1984 Mar 1;218(2):459-64. doi: 10.1042/bj2180459.
10
Regulation of mucosal phosphofructokinase in the small intestine of the streptozotocin-diabetic rat.链脲佐菌素诱导糖尿病大鼠小肠黏膜磷酸果糖激酶的调节
Diabetologia. 1983 Oct;25(4):355-9. doi: 10.1007/BF00253201.
Zotero 插件