Marks R, Dalziel K, Dykes P J
Br J Dermatol. 1984 Jul;111 Suppl 27:109-13. doi: 10.1111/j.1365-2133.1984.tb15588.x.
When an epidermoid cyst ruptures, a granulomatous infiltrate develops around the damaged structure. The same is true when other horn-containing cysts release their content into the epidermis. A similar type of inflammation may be observed in the dermis around disrupted and horn-filled follicles in acne vulgaris. In this paper we describe experiments in which a granulomatous inflammation has been produced in guinea-pig skin by the intracutaneous implantation of stratum corneum and discuss the potential of this system as a model for the inflammation in acne.
当表皮样囊肿破裂时,在受损结构周围会形成肉芽肿性浸润。当其他含角囊肿将其内容物释放到表皮时,情况也是如此。在寻常痤疮中,在破裂且充满角的毛囊周围的真皮中也可观察到类似类型的炎症。在本文中,我们描述了通过皮内植入角质层在豚鼠皮肤中产生肉芽肿性炎症的实验,并讨论了该系统作为痤疮炎症模型的潜力。