[Regulation of hydroxylation in position 21 of steroids in adrenal cortex cells of newborn rats, in culture. Utilization of aminoglutethimide and of exogenous steroids].

The use of aminoglutethimide at 5.10(-4) mol/l, inhibitor of endogenous steroidogenesis, and of exogenous progesterone (20 micrograms/ml) as substrate allowed the control of the steroid 21-hydroxylating reaction in cultured newborn rat adrenocortical cells. This method has been employed to show that the 21-hydroxylation by these cells is strongly induced by the adrenocorticotropic hormone (20 mU/ml).