Little J W, Falace D A
Dent Clin North Am. 1984 Jul;28(3):455-69.
Careful attention to patients' histories and their medical problems and consultation with their physicians should provide sound bases for selection of drugs. Antibiotic prophylaxis for patients with cardiovascular disorders is described for American Heart Association standards, but for other indications sound judgment based on the principles of antibiotic prophylaxis must be the rule. Patients with end-stage renal disease and severe liver impairment may be at risk with certain drugs. The most critical time for consideration of use of drugs during pregnancy is the first trimester. However, careful selection of drugs for use during the balance of the term can reduce the risk of harm to the mother and fetus.
仔细关注患者的病史及其医疗问题，并与他们的医生进行会诊，应为药物选择提供可靠依据。根据美国心脏协会的标准描述了心血管疾病患者的抗生素预防措施，但对于其他适应症，必须遵循基于抗生素预防原则的合理判断。终末期肾病和严重肝功能损害的患者使用某些药物可能有风险。孕期考虑用药的最关键时期是孕早期。然而，在孕期其余时间谨慎选择用药可降低对母亲和胎儿造成伤害的风险。
