Smith G F, Spiker D, Peterson C P, Cicchetti D, Justine P
J Pediatr. 1984 Aug;105(2):228-34. doi: 10.1016/s0022-3476(84)80118-3.
To evaluate the effects of megadoses of vitamins with minerals on the cognitive intelligence of children with Down syndrome, a two-group double-blind clinical trial was carried out with 56 school-aged children with Down syndrome. Children were evaluated at baseline, 4 months, and 8 months with a battery of standard psychologic tests, physical examinations, and blood tests. The two groups, which were well-matched is cognitive intelligence and other important subject characteristics at baseline, were not significantly different in intelligence and other test scores at the 4- or 8-month test periods. The particular megadoses of vitamins with minerals used in the study did not produce increased intelligence in the study population.
为评估大剂量维生素与矿物质对唐氏综合征患儿认知智力的影响，对56名学龄期唐氏综合征患儿进行了一项两组双盲临床试验。在基线期、4个月和8个月时，通过一系列标准心理测试、体格检查和血液检查对患儿进行评估。两组在基线期的认知智力和其他重要受试者特征方面匹配良好，在4个月或8个月测试期的智力和其他测试分数上无显著差异。该研究中使用的特定大剂量维生素与矿物质并未使研究人群的智力提高。
