McPhee M S, Thorndyke C W, Thomas G, Tulip J, Chapman D, Lakey W H
Lasers Surg Med. 1984;4(1):93-8. doi: 10.1002/lsm.1900040113.
Two prostate tumour models (Dunning R3327H and AT) were tested in rats to see if they were sensitive to hematoporphyrin-photoradiation therapy (HPD-PRT). The R3327H tumours were irradiated by implantation of a single fiber optic and the R3327 AT tumours were treated with implantation of four fiber optics simultaneously. Thermal measurements made at the tip of the fiber and up to 1 cm from the tip indicated temperature rises from 1.5 degree C to 20 degrees C at the tip and 0 degree to 8 degrees C distal to the tip, with power densities ranging from 100 mW to 500 mW. The R3327H tumour was controlled up to 8 weeks post-HPD-PRT, when the initial tumour size was 400-500 mm3. The R3327 AT tumours also respond to the HPD-PRT but a significant laser-induced thermal rise in the tumour is suspected.
在大鼠身上测试了两种前列腺肿瘤模型（邓宁R3327H和AT），以观察它们对血卟啉光辐射疗法（HPD-PRT）是否敏感。通过植入单根光纤对R3327H肿瘤进行照射，同时植入四根光纤对R3327 AT肿瘤进行治疗。在光纤尖端及距尖端1厘米处进行的热测量表明，尖端温度升高1.5摄氏度至20摄氏度，尖端远端温度升高0摄氏度至8摄氏度，功率密度范围为100毫瓦至500毫瓦。当初始肿瘤大小为400 - 500立方毫米时，R3327H肿瘤在HPD-PRT后长达8周得到控制。R3327 AT肿瘤也对HPD-PRT有反应，但怀疑肿瘤中存在明显的激光诱导热升高。
