MHC位点同种免疫后混合淋巴细胞反应中淋巴细胞增殖反应降低。
Depressed lymphoproliferative response in mixed leukocyte reaction after Mis-locus alloimmunization.
作者信息
Solana R, Alonso M C, de la Fuente M, Paniagua J A, Rojas R, Peña J
出版信息
Rev Esp Fisiol. 1984 Mar;40(1):1-4.
The proliferation of BALB/C lymphocytes preimmunized with Mis or H-2 incompatible cells in response to alloantigens was studied. The results show that preimmunization with Mis-incompatible spleen cells inhibits the lymphoproliferative response against alloantigens whereas preimmunization with H-2 incompatible spleen cells enhances it. It is suggested that Mis coded determinants activate suppressor mechanisms responsible for the unresponsiveness of these preimmunized lymphocytes against alloantigens.
研究了用Mls或H-2不相容细胞预免疫的BALB/C淋巴细胞对同种异体抗原的增殖反应。结果表明，用Mls不相容的脾细胞预免疫可抑制针对同种异体抗原的淋巴细胞增殖反应，而用H-2不相容的脾细胞预免疫则可增强该反应。提示Mls编码的决定簇激活了负责这些预免疫淋巴细胞对同种异体抗原无反应性的抑制机制。
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