Kuhn M, Gartmann J, Grob P J, Widder W, Hartmann G
Schweiz Med Wochenschr. 1984 Jun 23;114(25):925-7.
While Goodpasture syndrome was previously defined purely clinically by the combination of pneumorrhagia and glomerulonephritis, today the following immunologic criteria must also be satisfied: evidence, provided by immunofluorescent investigation of the kidneys and lungs, of antibasement membrane antibodies in the serum and linear deposits of immunoglobulins, due to direct apposition of antibasement membrane antibodies. Cases where the lesions are caused by immune complexes should no longer be designated as Goodpasture syndrome. In the light of one of our own cases of immune complex glomerulonephritis with pneumorrhagia, the question is raised whether this subdivision by means of immunologic investigations is meaningful for the clinician.
虽然过去古德帕斯丘综合征完全是通过肺出血和肾小球肾炎的临床组合来定义的，但如今还必须满足以下免疫学标准：通过对肾脏和肺部进行免疫荧光检查，证明血清中存在抗基底膜抗体以及由于抗基底膜抗体直接附着而产生的免疫球蛋白线性沉积。由免疫复合物引起病变的病例不应再被认定为古德帕斯丘综合征。鉴于我们自己遇到的一例伴有肺出血的免疫复合物性肾小球肾炎病例，就通过免疫学检查进行这种细分对临床医生是否有意义提出了疑问。
