Johnson J R, Priestman T J, Fotherby K, Kelly K A, Priestman S G
Br J Cancer. 1984 Sep;50(3):363-6. doi: 10.1038/bjc.1984.184.
The efficacy of high-dose intramuscular MPA therapy in controlling progressive measurable metastatic breast carcinoma was assessed in 32 women. In addition serial measurements of MPA blood levels were carried out in 20 of the patients and subjective effects of treatment were monitored in detail in 18 of the women. Overall 6 patients (19%) gained an objective response and a further 7 (22%) experienced disease stasis from 4-17 months whilst on treatment. Significant differences in serum MPA levels were seen between responders and non-responders, objective tumour shrinkage only being seen in those patients who rapidly attained, and sustained, blood levels in excess of 100 ng ml-1. Subjective assessment showed no evidence of a euphoriant effect of MPA therapy in the non-responders group.
对32名女性评估了大剂量肌肉注射甲羟孕酮（MPA）疗法在控制可测量的进展期转移性乳腺癌方面的疗效。此外，对20名患者进行了MPA血药浓度的系列测定，并对18名女性详细监测了治疗的主观效果。总体而言，6名患者（19%）获得客观缓解，另有7名患者（22%）在治疗期间4至17个月病情稳定。缓解者与未缓解者之间血清MPA水平存在显著差异，仅在那些迅速达到并维持血药浓度超过100 ng/ml的患者中观察到客观肿瘤缩小。主观评估显示，在未缓解组中没有证据表明MPA疗法有欣快效应。
