Fogelman I, Smith M L
Clin Rheumatol. 1982 Mar;1(1):41-4. doi: 10.1007/BF02032475.
The bone scan may be of value in the assessment of patients with metabolic bone disease. However the superiority of the bone scan when compared to radiology in conditions such as renal osteodystrophy, osteomalacia, primary hyperparathyroidism, and osteoporosis requires substantiation with the newer radiopharmaceuticals which have a higher affinity for bone. Two methods of quantitating skeletal uptake of tracer have been assessed to try to remove the subjective aspect of bone scan evaluation. Measurements of bone to soft tissue ratios have proved clinically disappointing, but 24 hour whole body retention of diphosphonate appears to provide a sensitive index of increased bone turnover.
骨扫描在评估代谢性骨病患者时可能具有价值。然而，在肾性骨营养不良、骨软化症、原发性甲状旁腺功能亢进和骨质疏松症等病症中，与放射学相比，骨扫描的优越性需要用对骨具有更高亲和力的新型放射性药物来证实。已经评估了两种定量示踪剂骨骼摄取的方法，试图消除骨扫描评估中的主观因素。骨与软组织比值的测量在临床上令人失望，但二膦酸盐的24小时全身滞留似乎提供了骨转换增加的敏感指标。
