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[使用单克隆抗体测定特应性皮炎患者循环淋巴细胞亚群]

[Determination of circulating lymphocyte subpopulations in atopic dermatitis using monoclonal antibodies].

作者信息

De Maubeuge J, Delespesse G, Achten G, Servais G, De Vetter L, Gaillaert N

出版信息

Dermatologica. 1984;169(1):6-11.

PMID:6236116
Abstract

Monoclonal antibodies were used to determine the level of circulating helper and suppressor T cells in 34 infants and adults with severe atopic dermatitis and in normal controls. The percentage of OKT3 (total T lymphocytes) was reduced significantly in all the atopic infants. The percentage of OKT8 (suppressor-cytotoxic T lymphocytes) was reduced significantly in all patients with active lesions. The percentage of T gamma lymphocytes was reduced in all the atopic patients with or without active lesions.

摘要

采用单克隆抗体测定了34例重症特应性皮炎婴幼儿及成人患者和正常对照者循环辅助性T细胞及抑制性T细胞水平。所有特应性皮炎婴幼儿的OKT3(总T淋巴细胞)百分比均显著降低。所有有活动性皮损的患者OKT8(抑制性-细胞毒性T淋巴细胞)百分比均显著降低。所有有或无活动性皮损的特应性皮炎患者Tγ淋巴细胞百分比均降低。

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