自身免疫效应细胞。VI. 用混合淋巴细胞培养中激活的脾细胞转移实验性变应性脑脊髓炎

Autoimmune effector cells. VI. Transfer of experimental allergic encephalomyelitis with spleen cells activated in mixed lymphocyte cultures.

作者信息

Hayosh N S, Simon L L, Swanborg R H

出版信息

J Immunol. 1984 Oct;133(4):1943-5.

Abstract

Although spleen cells (SpC) from Lewis rats that have been immunized with guinea pig myelin basic protein in complete Freund's adjuvant do not transfer experimental autoimmune encephalomyelitis (EAE) to syngeneic recipients, we report that effector cells of EAE can be activated in SpC suspensions during mixed lymphocyte reactions (MLR) to allogeneic SpC. Effector cell activation correlates with interleukin 2 (IL 2) production. The results are consistent with the hypothesis that autoreactive cells may be generated as a result of an immune response to exogenous antigens.

摘要

尽管在完全弗氏佐剂中用豚鼠髓鞘碱性蛋白免疫的Lewis大鼠的脾细胞（SpC）不会将实验性自身免疫性脑脊髓炎（EAE）转移给同基因受体，但我们报告称，在与异基因SpC的混合淋巴细胞反应（MLR）过程中，EAE的效应细胞可在SpC悬液中被激活。效应细胞的激活与白细胞介素2（IL-2）的产生相关。这些结果与自身反应性细胞可能因对外源抗原的免疫反应而产生的假说一致。

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Am J Pathol. 1986 Feb;122(2):218-22.

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