O'Brodovich H M, Coates G
J Pediatr. 1984 Sep;105(3):377-83. doi: 10.1016/s0022-3476(84)80008-6.
The quantitative assessment of regional pulmonary ventilation and perfusion provides useful information regarding lung function. Its use in infants and young children, however, has been minimal because of practical and technical limitations when the distribution of ventilation is assessed by radioactive gases. In 16 infants and children we used an inexpensive commercially available nebulizer to produce a submicronic aerosol labeled with 99mtechnetium-diethylenetriamine pentacetic acid to assess ventilation quantitatively, and intravenous injections of 99mtechnetium-labeled macroaggregates of albumin to assess pulmonary perfusion quantitatively. Studies were safely completed in both ambulatory and critically ill patients, including two premature infants who had endotracheal tubes in place for ventilatory support. No sedation or patient cooperation is required. This technique enables any department of nuclear medicine to measure regional pulmonary ventilation and perfusion in infants and children.
区域肺通气和灌注的定量评估可提供有关肺功能的有用信息。然而，由于使用放射性气体评估通气分布时存在实际和技术限制，其在婴幼儿中的应用一直很少。我们对16例婴幼儿使用一种廉价的市售雾化器，产生用99m锝-二乙烯三胺五乙酸标记的亚微米气溶胶来定量评估通气，并静脉注射99m锝标记的白蛋白大聚合体来定量评估肺灌注。在门诊和危重症患者中均安全地完成了研究，包括两名使用气管内插管进行通气支持的早产儿。无需镇静或患者配合。该技术使任何核医学科都能够测量婴幼儿的区域肺通气和灌注。
