[Allergic heparin-induced infiltrates and skin necrosis caused by subcutaneous injections of heparin].

Application of heparin in low doses to the treatment of 6 patients to prevent postoperative venous thromboembolic complications led to the development of an allergic heparin infiltrate (AHI). In three cases, the AHI eventuated in skin and subcutaneous fat necrosis, while in the remaining cases, underwent a reverse development. Apparently, the basis of the AHI is formed by the immediate type hypersensitivity developing in the area of repeated heparin injections. The AHI should be treated with glucocorticoids, antihistamine drugs, and antibiotics.