Moore G E, Harvey S, Klandorf H, Goldspink G
Gen Comp Endocrinol. 1984 Aug;55(2):195-9. doi: 10.1016/0016-6480(84)90101-1.
The metabolic and contractile activity of muscle was determined in immature cockerels made hypothyroid by surgical thyroidectomy at 6 weeks of age. Four weeks after thyroidectomy the activity of Mg2+-activated myofibrillar ATPase and total phosphorylase was reduced in the fast-phasic, posterior latissimus dorsi (PLD) and scapulotriceps (ST) muscles. The activities of these enzymes were unaffected in the slow-tonic, anterior latissimus dorsi (ALD) muscle. Thyroidectomy had no effect on length of the muscles studied but reduced the weight of the ALD and ST muscles. These results suggest that hypothyroidism results in a "slowing down" of fast-phasic muscles, although it does not affect the activity of slow-tonic muscles.
在6周龄时通过手术切除甲状腺使雏鸡甲状腺功能减退，以此来测定肌肉的代谢和收缩活性。甲状腺切除术后四周，快速收缩的背阔肌后部（PLD）和肱三头肌肩胛部（ST）肌肉中，镁离子激活的肌原纤维ATP酶和总磷酸化酶的活性降低。这些酶的活性在慢张力的背阔肌前部（ALD）肌肉中未受影响。甲状腺切除术对所研究肌肉的长度没有影响，但减少了ALD和ST肌肉的重量。这些结果表明，甲状腺功能减退会导致快速收缩肌肉“变慢”，尽管它不影响慢张力肌肉的活性。
