短期拉伸对兔主动脉血管收缩反应的影响。

The influence of short-duration stretch on vasoconstrictor response in rabbit aortas.

作者信息

Wolf G L, Lentini E A

出版信息

Invest Radiol. 1984 Jul-Aug;19(4):269-72. doi: 10.1097/00004424-198407000-00006.

DOI:10.1097/00004424-198407000-00006

Abstract

Circumferential strips of rabbit aorta were subjected to 60-second graded stretches in vitro. Before and after each stretch, the vasoconstrictor dose-responses to potassium and norepinephrine were measured. For stretch between 130 to 190% of resting length, vasoconstrictor response was progressively enhanced. However, arteries stretched 190 to 220% of resting length showed a significant fall in developed tension in response to either vasoconstrictor. Since arteries in vivo operate at 150 to 180% of resting length due to physiologic distention, it is likely that effective angioplasty does induce paralysis of vascular smooth muscle.

摘要

将兔主动脉的环形条带在体外进行60秒的分级拉伸。每次拉伸前后，测量对钾和去甲肾上腺素的血管收缩剂剂量反应。对于在静息长度的130%至190%之间的拉伸，血管收缩反应逐渐增强。然而，拉伸至静息长度的190%至220%的动脉对任何一种血管收缩剂的反应显示出张力显著下降。由于体内动脉因生理扩张而在静息长度的150%至180%下运作，有效的血管成形术很可能确实会导致血管平滑肌麻痹。