Carter C J
Neurosci Lett. 1984 Aug 10;48(3):339-42. doi: 10.1016/0304-3940(84)90061-2.
GABA transaminase activity is reduced in autopsied putamen samples from patients dying with Huntington's disease. Its activity is also reduced in the striatum of rats previously lesioned with kainic acid. In both cases, the reduction in GABA transaminase activity is comparable with the reduction in glutamate decarboxylase activity, supporting the suspected localization of this enzyme to GABA neurones within the basal ganglia.
死于亨廷顿舞蹈病患者的尸检壳核样本中，γ-氨基丁酸转氨酶活性降低。在先前用 kainic 酸损伤的大鼠纹状体中，其活性也降低。在这两种情况下，γ-氨基丁酸转氨酶活性的降低与谷氨酸脱羧酶活性的降低相当，这支持了该酶在基底神经节内γ-氨基丁酸神经元中的推测定位。
