唐氏综合征血小板中钙含量降低及45Ca2+摄取减少。

Decreased calcium content and 45Ca2+ uptake in Down's syndrome blood platelets.

作者信息

McCoy E E, Sneddon J M

出版信息

Pediatr Res. 1984 Sep;18(9):914-6. doi: 10.1203/00006450-198409000-00024.

DOI:10.1203/00006450-198409000-00024

Abstract

Total intracellular Ca2+ and 45Ca2+ uptake has been studied in blood platelets from subjects with Down's syndrome and matched controls. In Down's subjects, Ca2+ levels (85.5 +/- 5.9 nmol/10(-9) platelets) were significantly lower than controls, 174 +/- 10.0 nmol/10(-9) (p less than 0.0005). A similar reduction was seen in calcium uptake (Down's platelets, 0.79 +/- 0.06 nmol/10(-9) platelets; controls, 1.17 +/- 0.07 nmol/10(-9) platelets, p less than 0.005). The low levels of intracellular Ca2+ may be related to decreased granular storage of serotonin, and the decreased Ca2+ uptake with impaired transport by intracellular Ca2+-accumulating organelles such as the dense tubular system.

摘要

对唐氏综合征患者和匹配的对照组的血小板进行了细胞内总钙含量和45钙摄取的研究。唐氏综合征患者的钙水平（85.5±5.9纳摩尔/10⁻⁹个血小板）显著低于对照组，对照组为174±10.0纳摩尔/10⁻⁹个血小板（p<0.0005）。钙摄取也有类似的降低（唐氏综合征患者的血小板为0.79±0.06纳摩尔/10⁻⁹个血小板；对照组为1.17±0.07纳摩尔/10⁻⁹个血小板，p<0.005）。细胞内钙水平低可能与5-羟色胺颗粒储存减少有关，以及细胞内钙积累细胞器（如致密管状系统）运输受损导致钙摄取减少有关。