Zink R, Seifert J, Ring J, Brendel W
Res Exp Med (Berl). 1976 Jul 2;167(3):231-8. doi: 10.1007/BF01851647.
Two groups of dogs received daily intravenous doses of 20 mg/kg 131-I-labelled horse-anti-dog lymphocyte globulin or normal horse gammaglobulin respectively over a period of 11 days. Horse-anti-dog lymphocyte globulin showed a significantly higher eleimination rate than normal horse gammaglobulin. In contrary to the continuous increase in serum radioactivity during normal horse gammaglobulin treatment, there was a plateau after the 5th day in the horse-anti-dog lymphocyte globulin group. The xenogeneic protein concentration, measured with the single radial immunodiffusion technique, at the end of treatment was 165 +/- 8 mg/1 in the horse-anti-dog lymphocyte globulin, compared to 498 +/- 15 mg/1 in the normal horse gammaglobulin group. After treatment horse-anti-dog-lymphocyte globulin treated animals showed a significantly higher increase in active hemagglutination titer against horse erythrocytes with an average of 2(-8).
两组犬分别在11天内每日静脉注射20mg/kg的131-I标记的马抗犬淋巴细胞球蛋白或正常马丙种球蛋白。马抗犬淋巴细胞球蛋白的清除率明显高于正常马丙种球蛋白。与正常马丙种球蛋白治疗期间血清放射性持续增加相反，马抗犬淋巴细胞球蛋白组在第5天后出现平台期。治疗结束时，用单向放射免疫扩散技术测得的异种蛋白浓度，马抗犬淋巴细胞球蛋白组为165±8mg/1，而正常马丙种球蛋白组为498±15mg/1。治疗后，接受马抗犬淋巴细胞球蛋白治疗的动物对马红细胞的主动血凝滴度显著升高，平均为2（-8）。
