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牛垂体腺内胶体的显著特征:一种向垂体激素和免疫球蛋白传递决定因素的转运介质。

Salient characteristics of bovine pituitary intraglandular colloid: a transport medium for determinants to pituitary hormones and immunoglobulins.

作者信息

Boyd W H, Peters A

出版信息

Acta Biol Hung. 1983;34(4):363-9.

PMID:6237531
Abstract

Bovine hypophyseal intraglandular colloid, the holocrine secretion of marginal intermediate lobe cells, contains high molecular weight (MW 45 000 to 158 000) protein fractions and low molecular weight (MW below 25 000) peptide fractions. The fractions display immunoreactive determinants similar to those in pituitary hormones, cerebrospinal fluid (CSF), serum IgG and albumin. Immunoelectrophoresis shows that components in high molecular weight fractions distribute themselves in three distinct bands (gamma, beta, alpha), while those in low molecular weight fractions distribute themselves in two bands (gamma and alpha). Physiochemical characteristics, i.e., sedimentation rate, percentage of hexose, total CHO and 12C as well as the content of cystine are presented. It is concluded that pituitary colloid should not be dismissed as a waste product of cellular degeneration, since there are strong suggestions that it serves as a transport medium for certain pituitary hormones.

摘要

牛垂体腺内胶体是边缘中间叶细胞的全质分泌产物,含有高分子量(分子量45000至158000)蛋白质组分和低分子量(分子量低于25000)肽组分。这些组分显示出与垂体激素、脑脊液(CSF)、血清IgG和白蛋白中相似的免疫反应决定簇。免疫电泳显示,高分子量组分中的成分分布在三条不同的带(γ、β、α)中,而低分子量组分中的成分分布在两条带(γ和α)中。文中给出了其物理化学特性,即沉降率、己糖百分比、总CHO和12C以及胱氨酸含量。得出的结论是,垂体胶体不应被视为细胞变性的废物,因为有充分迹象表明它作为某些垂体激素的运输介质。

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