Gilfillan E C, Pelak B A, Bland J A, Malatesta P F, Gadebusch H H
Chemotherapy. 1984;30(5):288-96. doi: 10.1159/000238283.
Pharmacokinetic studies were conducted with norfloxacin administered by the oral and subcutaneous routes to mice and rats, and by the oral route to rhesus monkeys. The compound was moderately well absorbed following oral dosing in these animal species. Serum levels in monkeys ranged from 1.0 to 2.35 micrograms/ml after an oral drug dose of 25 mg/kg of animal body weight and were similar to those in mice. Serum half-life of norfloxacin in rodents and monkeys was similar to that in humans. Concentrations of norfloxacin in tissues of mice, rats and monkeys were greater than those in serum suggesting a large volume of distribution for the drug.
对小鼠、大鼠进行了诺氟沙星经口服和皮下途径给药的药代动力学研究，并对恒河猴进行了经口服途径给药的药代动力学研究。在这些动物物种中，口服给药后该化合物吸收情况中等。给予动物体重25mg/kg的口服药物剂量后，猴子的血清水平在1.0至2.35微克/毫升之间，与小鼠的血清水平相似。诺氟沙星在啮齿动物和猴子体内的血清半衰期与人类相似。诺氟沙星在小鼠、大鼠和猴子组织中的浓度高于血清中的浓度，表明该药物的分布容积较大。
