Solimando D A, Wilson J P
Drug Intell Clin Pharm. 1984 Oct;18(10):808-11. doi: 10.1177/106002808401801007.
An uncommon side effect of the anthracycline antibiotics is allergic reactions. We report three patients treated with doxorubicin hydrochloride who developed systemic hypersensitivity reactions to the drug. In all three cases, the onset of the reaction coincided with the initiation of the doxorubicin, and was confirmed by rechallenge with the drug. An urticarial rash with pruritus was the primary clinical manifestation seen in all cases. All reactions responded to treatment with diphenhydramine, or diphenhydramine and hydrocortisone. None of the reactions were life-threatening or required hospitalization of the patient. In two patients, use of the drug was discontinued because of the reaction. Pretreatment with diphenhydramine, prednisone, and cimetidine may have reduced the severity of the reaction in one patient.
蒽环类抗生素一种不常见的副作用是过敏反应。我们报告了3例接受盐酸多柔比星治疗的患者，他们对该药物发生了全身性过敏反应。在所有3例病例中，反应的发生与多柔比星的开始使用时间一致，并且通过再次使用该药物得到了证实。伴有瘙痒的荨麻疹皮疹是所有病例中主要的临床表现。所有反应均对苯海拉明或苯海拉明与氢化可的松的治疗有反应。没有一个反应危及生命或需要患者住院治疗。在2例患者中，由于反应而停用了该药物。在1例患者中，苯海拉明、泼尼松和西咪替丁的预处理可能减轻了反应的严重程度。
