Sklar C A, Ulstrom R A
Horm Res. 1984;20(3):166-71. doi: 10.1159/000179991.
The effect of human growth hormone (hGH) on adrenal androgen secretion was assessed in 7 patients (5 males, 2 females) with GH deficiency but normal ACTH-cortisol function. Patients ranged in age from 9 5/12 to 14 8/12 years (median 12 years). Plasma concentrations of dehydroepiandrosterone-sulfate (DHEA-S) and urinary excretion of 17-ketosteroids (17-KS) and free cortisol were determined before, during short-term (2 U/day X 3) and after long-term (6 months) treatment with hGH. No significant change was noted in the plasma concentration or urinary excretion of steroids during the short-term administration of hGH. Despite a significant increase in growth velocity during 6 months of hGH therapy (8.2 vs. 4.5 cm/year, p less than 0.01), the plasma concentrations of DHEA-S and the urinary 17-KS and free cortisol levels were unchanged. These results fail to substantiate a role for hGH in the physiologic control of adrenal androgen secretion. Thus, the low plasma levels of adrenal androgens sometimes seen in GH-deficient patients are not due to the absence of GH per se.
在7例生长激素（hGH）缺乏但促肾上腺皮质激素-皮质醇功能正常的患者（5例男性，2例女性）中评估了hGH对肾上腺雄激素分泌的影响。患者年龄范围为9又5/12岁至14又8/12岁（中位数12岁）。在短期（2单位/天×3天）和长期（6个月）hGH治疗前、治疗期间及治疗后，测定了硫酸脱氢表雄酮（DHEA-S）的血浆浓度、17-酮类固醇（17-KS）的尿排泄量和游离皮质醇。在短期给予hGH期间，类固醇的血浆浓度或尿排泄量未观察到显著变化。尽管在6个月的hGH治疗期间生长速度显著增加（8.2对4.5厘米/年，p<0.01），但DHEA-S的血浆浓度、尿17-KS和游离皮质醇水平未改变。这些结果未能证实hGH在肾上腺雄激素分泌的生理控制中起作用。因此，生长激素缺乏患者中有时可见的低血浆肾上腺雄激素水平并非由于生长激素本身的缺乏。
