Miedema F, Willemze R, Terpstra F G, van Vloten W A, Meijer C J, Melief C J
Leuk Res. 1984;8(5):873-84. doi: 10.1016/0145-2126(84)90108-5.
Functional activities and surface markers of the neoplastic T cells of three patients with Sézary syndrome were studied and compared with the functional activities of OKT4+ and OKT8+ T-cell subsets from healthy donors. The neoplastic T cells of the patients had the following marker phenotype: OKT1+3+4+6-8-11+17+I1-M1-3A1-. In contrast to healthy donor OKT4+ T cells, none of the neoplastic T cells had significant helper activity on pokeweed-mitogen-driven Ig synthesis. In one patient the neoplastic T cells suppressed pokeweed-mitogen-driven Ig synthesis. The suppression by the patient cells did not require the presence of radiosensitive OKT4+ suppressor-inducer cells in the culture. It is concluded that OKT4+8-3A1- neoplastic T cells from Sézary-syndrome patients lacking helper activity are more common than previously thought and that in some cases the OKT4+8-3A1- Sézary cells can mediate suppressor activity.
对三名蕈样肉芽肿综合征患者的肿瘤性T细胞的功能活性和表面标志物进行了研究，并与健康供体的OKT4 +和OKT8 + T细胞亚群的功能活性进行了比较。患者的肿瘤性T细胞具有以下标志物表型：OKT1 + 3 + 4 + 6 - 8 - 11 + 17 + I1 - M1 - 3A1 - 。与健康供体的OKT4 + T细胞不同，肿瘤性T细胞在商陆有丝分裂原驱动的Ig合成中均无显著的辅助活性。在一名患者中，肿瘤性T细胞抑制了商陆有丝分裂原驱动的Ig合成。患者细胞的抑制作用不需要培养物中存在放射敏感的OKT4 +抑制诱导细胞。得出的结论是，缺乏辅助活性的蕈样肉芽肿综合征患者的OKT4 + 8 - 3A1 - 肿瘤性T细胞比以前认为的更常见，并且在某些情况下，OKT4 + 8 - 3A1 - 蕈样肉芽肿细胞可介导抑制活性。
