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醋酸甲羟孕酮(长效避孕针)对狒狒(埃及狒狒)产前发育的影响:一项初步研究。

The effect of medroxyprogesterone acetate (Depo-Provera) on prenatal development in the baboon (Papio anubis): a preliminary study.

作者信息

Tarara R

出版信息

Teratology. 1984 Oct;30(2):181-5. doi: 10.1002/tera.1420300205.

DOI:10.1002/tera.1420300205
PMID:6238440
Abstract

Six female olive baboons (Papio cynocephalus anubis) were treated with a single dose of 150 mg of Depo-Provera i.m. at day 30 of pregnancy, approximately three times the human dose equivalent on a body weight basis. Fetectomies were performed at day 100 of gestation. The body weights and measurements of the five live fetuses were comparable to age-matched controls and no gross or histologic abnormalities were seen. The dead fetus was in an advanced state of decomposition. This preliminary study suggests that, at levels up to three times that used for human contraception, Depo-Provera does not appear to have any adverse effects on fetal development.

摘要

六只雌性东非狒狒(埃及狒狒)在妊娠第30天接受了单次肌肉注射150毫克醋酸甲羟孕酮的治疗,按体重计算约为人类等效剂量的三倍。在妊娠第100天进行了取胎手术。五只活胎的体重和测量值与年龄匹配的对照组相当,未发现明显的大体或组织学异常。死胎处于晚期分解状态。这项初步研究表明,在高达人类避孕所用剂量三倍的水平下,醋酸甲羟孕酮似乎对胎儿发育没有任何不良影响。

相似文献

1
The effect of medroxyprogesterone acetate (Depo-Provera) on prenatal development in the baboon (Papio anubis): a preliminary study.醋酸甲羟孕酮(长效避孕针)对狒狒(埃及狒狒)产前发育的影响:一项初步研究。
Teratology. 1984 Oct;30(2):181-5. doi: 10.1002/tera.1420300205.
2
Reply to Dr. Edwin B. McDaniel. Exaggerated claims of depo-provera safety.回复埃德温·B·麦克丹尼尔博士。关于醋酸甲羟孕酮安全性的夸大说法。
Women Health. 1981 Spring-Summer;6(1-2):125-9.
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Depo-provera: contraceptive risk?醋酸甲羟孕酮避孕针:有避孕风险吗?
Hastings Cent Rep. 1980 Apr;10(2):4.
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Embryotoxicity and maternal serum concentrations of medroxyprogesterone acetate (MPA) in baboons (Papio cynocephalus).狒狒(黄狒狒)中醋酸甲羟孕酮(MPA)的胚胎毒性及母体血清浓度
Contraception. 1985 Nov;32(5):497-515. doi: 10.1016/0010-7824(85)90020-4.
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Depo-Provera in adolescents: effects of early second injection or prior oral contraception.青少年使用醋酸甲羟孕酮避孕针:第二次提前注射或先前口服避孕药的影响。
J Adolesc Health. 1995 May;16(5):379-84. doi: 10.1016/S1054-139X(95)00094-9.
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Depo-Provera: an injectable contraceptive.
Nurs Times. 1981;77(42):1794-8.
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Injectable contraception.注射用避孕药
IPPF Med Bull. 1980 Dec;14(6):1-3.
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Embryotoxicity of a single dose of medroxyprogesterone acetate (MPA) and maternal serum MPA concentrations in cynomolgus monkey (Macaca fascicularis).单剂量醋酸甲羟孕酮(MPA)对食蟹猴(猕猴)的胚胎毒性及母体血清MPA浓度
Teratology. 1985 Dec;32(3):421-32. doi: 10.1002/tera.1420320312.
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Effect of non-antiovulatory doses of norethindrone & depoprovera on implantation in rat.炔诺酮及醋酸甲羟孕酮的非抗排卵剂量对大鼠着床的影响。
Indian J Biochem Biophys. 1980 Aug;17(4):294-7.
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Teratogenic effects of cyproterone acetate and medroxyprogesterone treatment during the pre- and postimplantation period of mouse embryos. I.醋酸环丙孕酮和甲羟孕酮在小鼠胚胎植入前和植入后阶段治疗的致畸作用。I.
Teratology. 1982 Feb;25(1):27-36. doi: 10.1002/tera.1420250105.

引用本文的文献

1
Serum concentrations of medroxyprogesterone acetate were undetectable on OPU+5 days and had no effect on the serum progesterone level in patients undergoing the progestin-primed ovarian stimulation protocol.在取卵后5天时,醋酸甲羟孕酮的血清浓度无法检测到,且对接受孕激素预处理卵巢刺激方案的患者的血清孕酮水平没有影响。
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