Tarara R
Teratology. 1984 Oct;30(2):181-5. doi: 10.1002/tera.1420300205.
Six female olive baboons (Papio cynocephalus anubis) were treated with a single dose of 150 mg of Depo-Provera i.m. at day 30 of pregnancy, approximately three times the human dose equivalent on a body weight basis. Fetectomies were performed at day 100 of gestation. The body weights and measurements of the five live fetuses were comparable to age-matched controls and no gross or histologic abnormalities were seen. The dead fetus was in an advanced state of decomposition. This preliminary study suggests that, at levels up to three times that used for human contraception, Depo-Provera does not appear to have any adverse effects on fetal development.
六只雌性东非狒狒(埃及狒狒)在妊娠第30天接受了单次肌肉注射150毫克醋酸甲羟孕酮的治疗,按体重计算约为人类等效剂量的三倍。在妊娠第100天进行了取胎手术。五只活胎的体重和测量值与年龄匹配的对照组相当,未发现明显的大体或组织学异常。死胎处于晚期分解状态。这项初步研究表明,在高达人类避孕所用剂量三倍的水平下,醋酸甲羟孕酮似乎对胎儿发育没有任何不良影响。