均匀有髓纤维传导的模拟。对节点和节间参数变化的相对敏感性。
Simulations of conduction in uniform myelinated fibers. Relative sensitivity to changes in nodal and internodal parameters.
作者信息
Moore J W, Joyner R W, Brill M H, Waxman S D, Najar-Joa M
出版信息
Biophys J. 1978 Feb;21(2):147-60. doi: 10.1016/S0006-3495(78)85515-5.
Abstract
Conduction of impulses in myelinated axons has been studied by a new method of computer simulation. The contributions of nodal and internodal characteristics and parameters were examined. Surprisingly, the conduction velocity, theta, was found to be quite insensitive to the nodal area or the exact description of its excitable processes. The conduction velocity also is relatively insensitive to the internodal length but much more sensitive to the myelin capacitance and axoplasm conductance. Qualitative change in theta with temperature depended on which temperature-sensitive parameters were included in the simulation.
摘要
通过一种新的计算机模拟方法研究了有髓鞘轴突中的冲动传导。研究了节点和节间特征及参数的作用。令人惊讶的是，发现传导速度θ对节点面积或其兴奋过程的精确描述相当不敏感。传导速度对节间长度也相对不敏感，但对髓鞘电容和轴浆电导更为敏感。θ随温度的定性变化取决于模拟中包含哪些温度敏感参数。
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