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[Lati:CFLP 群体中不育雄性小鼠的减数分裂紊乱]

[Disordered meiosis in sterile male mice in a Lati:CFLP colony].

作者信息

Malashenko A M, Buczolics E, Nadudvari I

出版信息

Biull Eksp Biol Med. 1984 Oct;98(10):486-8.

PMID:6238639
Abstract

The incidence rate of sterile male mice in a Lati:CFLP colony was studied. It was established to amount to 0.33 +/- 011%. Part of sterile males (about 64%) had reduced weight testicles. Cytological analysis revealed spermatogenesis blockade because of spermatocyte death in the late prophase and metaphase I meiosis in these animals. It is concluded that in the mouse colony under study, genetic factor (chromosome rearrangement or gene mutation) is maintained, which determines meiosis blockade in male mice-bearers of this factor.

摘要

对Lati:CFLP群体中雄性不育小鼠的发病率进行了研究。确定其发病率为0.33±0.11%。部分不育雄性小鼠(约64%)睾丸重量减轻。细胞学分析显示,这些动物减数分裂前期晚期和中期I的精母细胞死亡导致精子发生阻滞。得出的结论是,在该研究的小鼠群体中,存在一种遗传因素(染色体重排或基因突变),该因素决定了携带此因素的雄性小鼠减数分裂阻滞。

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