Rădulescu E
Morphol Embryol (Bucur). 1984 Jul-Sep;30(3):205-10.
Cytomorphologic and cytoenzymochemical changes occurring in leukemic blastic cells of bone marrow and peripheral blood were studied concomitantly in 180 cases of acute leukemia treated with one or more cytostatics, in various association related to the main cytologic type. Cellular effects due to monochemotherapy in various types of acute leukemia varied depending on the cytostatic dose, duration of treatment, and sensitivity of blastic cells to the cytostat. The expression of cellular sensitivity was marked by megaloblastosis of myeloid elements, cell gigantism and intranuclear and cytoplasmic vacuolization. Resistance to cytostatics was demonstrated both by the morphologic aspect of blastic cells which remained unchanged and by their overloading with glycogen, lipids and peroxidases. The relationships between posttherapeutic cellular changes and clinical parameters are discussed.
对180例接受一种或多种细胞抑制剂治疗的急性白血病患者进行了研究，同时观察了骨髓和外周血白血病原始细胞中发生的细胞形态学和细胞酶化学变化，这些患者接受了与主要细胞学类型相关的各种联合治疗。不同类型急性白血病中单一化疗的细胞效应因细胞抑制剂剂量、治疗持续时间以及原始细胞对细胞抑制剂的敏感性而异。细胞敏感性的表现为髓系成分的巨幼样变、细胞巨大症以及核内和胞质空泡化。原始细胞形态未发生变化以及糖原、脂质和过氧化物酶过载均表明对细胞抑制剂具有抗性。文中讨论了治疗后细胞变化与临床参数之间的关系。
