苯巴比妥和醋酸甲羟孕酮对化学性肝损伤大鼠药物及葡萄糖代谢影响的比较。

A comparison of the effects of phenobarbital and medroxyprogesterone acetate on drug and glucose metabolism in rats with chemical liver injury.

作者信息

Stengård J H

出版信息

Res Commun Chem Pathol Pharmacol. 1984 Oct;46(1):67-76.

Abstract

The effects of medroxyprogesterone acetate (MPA) and phenobarbital (PB) on hepatic glucose and drug metabolism were investigated in male rats after liver injury, induced with dimethylnitrosamine (DMN). MPA normalized fasting blood glucose (BG) and serum immunoreactive insulin (IRI) levels and enhanced hepatic glucose-6-phosphatase (G6Pase) and NADPH cytochrome P450 reductase activities and glycogen and cytochrome P450 (cytP450) contents after liver injury. PB improved hepatic glycogen and cytP450 contents and NADPH cytP450 reductase activity in DMN pretreated rats. The increase in drug metabolism was more pronounced after PB than MPA therapy whereas MPA had more effect on glucose metabolism than had PB. This suggests that the inducing properties of these compounds diverge from each other.

摘要

在雄性大鼠中，研究了醋酸甲羟孕酮（MPA）和苯巴比妥（PB）对肝损伤（由二甲基亚硝胺（DMN）诱导）后肝脏葡萄糖和药物代谢的影响。MPA使肝损伤后的空腹血糖（BG）和血清免疫反应性胰岛素（IRI）水平恢复正常，并增强了肝脏葡萄糖-6-磷酸酶（G6Pase）和NADPH细胞色素P450还原酶活性以及糖原和细胞色素P450（cytP450）含量。PB改善了DMN预处理大鼠的肝脏糖原和cytP450含量以及NADPH cytP450还原酶活性。PB治疗后药物代谢的增加比MPA治疗更明显，而MPA对葡萄糖代谢的影响比PB更大。这表明这些化合物的诱导特性彼此不同。