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乳腺癌患者外周血淋巴细胞中吞噬细胞数量增加。

Increased number of phagocytic cells among the peripheral blood lymphocytes of mammary tumor patients.

作者信息

Süss J, Bakács T, Ringwald G

出版信息

Allerg Immunol (Leipz). 1984;30(3):183-7.

PMID:6239528
Abstract

Blood lymphocytes of 15 malignant mammary tumor patients and 16 healthy blood donors were tested for latex particle phagocytosis. The mononuclear cell fraction of breast cancer patients has been shown to contain significantly higher number of phagocytic cells (39.13 +/- 13.93%) compared to the values of healthy controls (20.34 +/- 6.96%) (p less than 0.01). It was demonstrated that the majority of phagocytic cells adhered to the glass of the hemocytometer, thus they could be distinguished morphologically from the non-adherent, non-phagocytic cells. The number of ingested latex particles per phagocytic cell was also higher in patients. This result shows that the activity of phagocytic cells was also increased in mammary tumor patients compared to controls.

摘要

对15名恶性乳腺肿瘤患者和16名健康献血者的血液淋巴细胞进行了乳胶颗粒吞噬作用测试。结果显示,乳腺癌患者的单核细胞部分所含吞噬细胞数量(39.13±13.93%)显著高于健康对照组(20.34±6.96%)(p<0.01)。已证实,大多数吞噬细胞附着在血细胞计数器的载玻片上,因此在形态上可与未附着、无吞噬作用的细胞区分开来。患者每个吞噬细胞摄取的乳胶颗粒数量也更多。这一结果表明,与对照组相比,乳腺肿瘤患者吞噬细胞的活性也有所增强。

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