Hanson M, Polesky H F
Am J Clin Pathol. 1984 Dec;82(6):716-9. doi: 10.1093/ajcp/82.6.716.
Two serologic markers, anti-HBs, -HBc, are useful to determine whether individuals at risk for hepatitis B virus infection are candidates for hepatitis B vaccination. To evaluate the usefulness of these markers in detecting immunity from prior infection (usually asymptomatic), 192 anti-HBs positive health care workers were tested for anti-HBc. In the 68% of individuals with anti-HBs RIA ratios greater than 10, anti-HBc was found in only 75%. In the group with anti-HBs ratios less than 10, only 6.6% had anti-HBc. Health care workers with frequent contact with blood and other body fluids were more likely to have both markers present. The incidence of the markers in this group was similar to that observed in 520 homosexually active males. The authors conclude that anti-HBs is more likely to identify prior immunity, particularly in individuals with infrequent HBV exposures.
两种血清学标志物，抗-HBs和抗-HBc，对于确定有感染乙型肝炎病毒风险的个体是否适合接种乙肝疫苗很有用。为了评估这些标志物在检测既往感染（通常无症状）所产生的免疫力方面的作用，对192名抗-HBs阳性的医护人员进行了抗-HBc检测。在抗-HBs放射免疫分析（RIA）比值大于10的个体中，仅75%检测到抗-HBc。在抗-HBs比值小于10的组中，只有6.6%有抗-HBc。经常接触血液和其他体液的医护人员更有可能同时具备这两种标志物。该组中这些标志物的发生率与在520名有同性恋行为的男性中观察到的相似。作者得出结论，抗-HBs更有可能识别既往免疫力，尤其是在乙肝病毒暴露不频繁的个体中。
