Crona N, Enk L, Samsioe G, Silfverstolpe G
Arch Gynecol. 1984;236(1):35-40. doi: 10.1007/BF02114866.
Twenty women, oophorectomized as part of treatment for cervical carcinoma of the cervix participated in the study. Ten of them were given desogestrel (DG) 150 micrograms/day for 3 weeks followed by DG + 30 micrograms ethinyl estradiol (EE) for 6 weeks, and finally EE alone for 3 weeks. The other 10 women were given 150 micrograms levonorgestrel (NORG) and EE in a similar way. Before treatment and after each period of treatment the relative fatty acid composition of serum lecithin and serum cholesterol ester were assessed by gas-liquid chromatography. In both groups ethinyl estradiol, when administered alone, increased arachidonic acid in serum lecithin. This increase was not observed on the DG + EE or the NORG + EE combination indicating that both progestins counteracted this estrogenic effect.
20名因宫颈癌接受卵巢切除术的女性参与了该研究。其中10名女性每天服用150微克去氧孕烯（DG），持续3周，随后服用DG + 30微克炔雌醇（EE），持续6周，最后仅服用EE，持续3周。另外10名女性以类似方式服用150微克左炔诺孕酮（NORG）和EE。在治疗前以及每个治疗阶段后，通过气液色谱法评估血清卵磷脂和血清胆固醇酯的相对脂肪酸组成。在两组中，单独服用炔雌醇时，血清卵磷脂中的花生四烯酸增加。在DG + EE或NORG + EE组合中未观察到这种增加，表明两种孕激素都抵消了这种雌激素作用。
