假定的血清素受体激动剂8-羟基-2-（二正丙基氨基）四氢萘（8-OH-DPAT）的抗冲突作用
Anticonflict effect of the putative serotonin receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT).
作者信息
Engel J A, Hjorth S, Svensson K, Carlsson A, Liljequist S
出版信息
Eur J Pharmacol. 1984 Oct 15;105(3-4):365-8. doi: 10.1016/0014-2999(84)90634-4.
The putative 5-HT agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OHDPAT) produced in rats an increase in the number of shocks accepted in a modified Vogel's conflict test design. Subchronic pretreatment with p-chlorophenylalanine (PCPA) similarly caused release of the punished behavior. This anticonflict effect of PCPA was antagonized by both 5-hydrotryptophan and 8-OH-DPAT. Thus in naive animals 8-OH-DPAT exerting anticonflict effects acted like a 5-HT antagonist, whereas in subchronically PCPA-pretreated animals with presumably supersensitive 5-HT receptors, 8-OH-DPAT decreasing the number of accepted shocks acted like a 5-HT agonist.
假定的5-羟色胺激动剂8-羟基-2-（二正丙基氨基）四氢萘（8-OHDPAT）在大鼠身上，采用改良的沃格尔冲突试验设计时，会使接受电击的次数增加。用对氯苯丙氨酸（PCPA）进行亚慢性预处理同样会导致受罚行为的释放。PCPA的这种抗冲突作用被5-羟色氨酸和8-OH-DPAT两者所拮抗。因此，在未处理的动物中，发挥抗冲突作用的8-OH-DPAT表现得像一种5-羟色胺拮抗剂，而在亚慢性PCPA预处理的、可能具有超敏5-羟色胺受体的动物中，减少接受电击次数的8-OH-DPAT表现得像一种5-羟色胺激动剂。
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